There are times when one needs to use safe mode in Windows either to remove malware or fix some corrupted system files and so on.
Here,it can be annoying to keep hitting F8 on every restart just to get into safe mode for troubleshooting as missing that will start Windows in normal mode.
Msconfig helps in making Windows boot in safe mode always.
In Vista :
1.Go to Start > Run > msconfig.
2.Select Boot tab and check the Safe boot option with sub option as Minimal.
3.Click Ok and select Exit without Restart option.(The settings will be applicable only on the next restart).
4.Restarting Windows with the above settings will now directly launch safe mode.
5.Remove the check mark on Safe boot to reverse these changes once work is done in safe mode.
Happy troubleshooting in safe mode.
Cheers.